BIOGRAPHICAL SKETCH

Mikulas Chavko: Research Physiologist/Chief Scientist Naval Medical Research Center, Silver Spring, MD

INSTITUTION DEGREE YEAR FIELD OF STUDY
Czech Technical University, Prague M.S. 1968 Physical Chemistry
University of Veternary Medicine, Kosice Ph.D. 1975 Biochemistry
Comenius University, Bratislava Sc.D. 1989 Biology

POSITIONS AND EMPLOYMENT

Chronological Employment
  • 1973-1976: Postdoctoral Fellow; Institute of Neurobiology., Kosice Czechoslovakia
  • 1976-1990: Research Biochemist, Institute of Neurobiology, Kosice, Czechoslovakia
  • 1990-1991: Research Associate, University of Pittsburgh Medical School, Department of Anesthesiology, Pittsburgh, PA
  • 1991-1993: Department Head; Institute of Neurobiology, Kosice, Czechoslovakia
  • 1993-1994: Senior Research Associate, National Research Council, Washington, DC
  • 1994-1997: Associate Professor, University of Pittsburgh Medical School, Department of Neurological Surgery, Pittsburgh, PA
  • 1997-2007: Senior Scientist, Principal Investigator, Henry Jackson Foundation for Military Medicine, Rockville, MD
  • 2007-:     Research Physiologist, Chief Scientist, Naval Medical Research Center, Silver Spring, MD, Assistant Professor, Uniformed Services University of Health Sciences, Department of Emergency Medicine, Bethesda, MD

SELECTED PUBLICATIONS

  1. Chavko, M., Harabin,A. L (1996). Regional lipid peroxidation and protein oxidation in rat brain after hyperbaric oxygen exposure. Free Radicals Biol. Med., 20:973-978.
  2. Lukacova, N; Halat, G., Chavko, M., Marsala, J. (1996). Ischemia-reperfusion injury in the spinal cord of rabbits strongly enhances lipid peroxidation and modifies phospholipid profiles Neurochem. Res., 21:869-73.
  3. Burda, J., Gottlieb, M., Chavko, M., Marsala, J., Alcazar. A., Pavon, M., Fando, J.L., Salinas, M. (1998). The intraischemic and early reperfusion changes of protein synthesis in the rat brain eiIF-2a kinase activity and role of initiation factors eIF-2a and eIF-4E. J. Cereb. Blood Flow Metabol., 18:59-66.
  4. Danielisova, V., Chavko, M. (1998). Comparative effect of non-competitive glutamate receptor antagonist MK-801 and calcium channel blocker KB-276 on functional and metabolic recovery after spinal cord ischemia.. Exp. Neurol., 149:203-208.
  5. Chavko, M., Braisted, J.C., Outsa, N.J., Harabin, A.L. (1998). Role of cerebral blood flow in seizures from hyperbaric oxygen exposures. Brain Res., 791:75-82.
  6. Chavko, M., Braisted, J.C., Harabin, A.L. (1998). Effect of MK-801 on seizures induced by exposure to hyperbaric oxygen: Comparison with AP-7. Toxicol. Appl. Pharmacol., 151:222-228.
  7. Chavko, M., Braisted, J.C., Harabin, A.L. (1999). Amelioration of hyperbaric O2 seizures by fasting is not related to ketosis. Undersea & Hyperb. Med., 26:99-103.
  8. Chavko, M., Xing, G.-Q., Keyser, D.O. (2001). Increased sensititivity to seizures in repeated exposures to hyperbaric oxygen; Role of nitric oxide synthase activation. Brain Res., 900: 227-233.
  9. Xing, G., Chavko, M., Zhang, L.X., Yang, S., Post, R.M. (2002). Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression. Schizophrenia Res., 58: 21-30.
  10. Chavko, M., Nadi, S.N., Keyser, D.O. (2002). Activation of BDNF mRNA and protein after seizures in hyperbaric oxygen. Implications for sensitization to seizures in re-exposures. Neurochem. Res., 27: 1641-1646.
  11. Chavko, M., Auker, C.R., McCarron, R.M. (2003). Relationship between protein nitration and oxidation and development of hyperoxic seizures. Nitric Oxide, 9: 18-23.
  12. Chavko, M., McCarron, R.M. (2006). Extension of brain tolerance to hyperbaric O2 by intermittent air breaks is related to the time of CBF increase. Brain Res. 1084: 197-202.
  13. Chavko, M., Prusaczyk, W.K., McCarron, R.M. (2006). Lung injury and recovery after exposure to blast overpressure. J. Trauma 61: 933-942.
  14. Chavko, M., Koller, W.A. Prusaczyk, W.K., McCarron, R.M. (2007). Detection of pressure wave in the rat brain exposed to blast overpressure by a miniature fiber optic pressure sensor. J. Neurosci. Methods, 159:277-281.
  15. Zitnanova, I., Sumegova, K., Simko, M., Maruniakova, A., Chovanova, Z., Chavko, M., Durackova, Z. (2007) Protein carbonyls as a biomarker of foetal-neonatal hypoxic stress. Clin Biochem., 40:567-70.
  16. Chavko, M., Mahon, R.T., McCarron, R.M. (2008). Mechanisms of protection against pulmonary hyperbaric O2 toxicity by intermittent air breaks. Eur. J. Appl. Physiol., 102:525-532.
  17. Chavko, M., Prusaczyk, W.K., McCarron, R.M. (2008). Protection against mortality after blast exposure by hemin. J. Trauma (in press).
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